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Predicting analysis time in event-driven clinical trials with event-reporting lag

✍ Scribed by Jianming Wang; Chunlei Ke; Qi Jiang; Charlie Zhang; Steven Snapinn


Book ID
112207030
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
235 KB
Volume
31
Category
Article
ISSN
0277-6715

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Exploration of the variation of treatment effect over time in randomized clinical trials with low event rates is limited by lack of power. A meta-analysis on individual patient data from such trials can partly solve the problem, but brings other computational difficulties. Using an example in hypert