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Precursor cell types in the germinal zone of the cerebral cortex

✍ Scribed by Brenda P. Williams


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
303 KB
Volume
17
Category
Article
ISSN
0265-9247

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✦ Synopsis


Retroviral lineage tracing experiments suggest that the cortical ventricular zone is composed of a mixture of precursor cell types. The majority generate a single cell type (neurones, astrocytes or oligodendrocytes) and the remainder generate neurones and a single type of glial cell. Pluripotential precursor cells, that have the ability to generate all three cell types, are not observed. A recent paper, however, reports that when single ventricular zone cells are cultured in isolation, a small percentage of these cells are pIuripotential(l). This review will discuss what this knowledge tells us about cortical development.


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