The development of the cerebral cortex requires large-scale movement of neurons from areas of proliferation to areas of differentiation and adult function in the cortex proper, and the patterns of this neuronal migration are surprisingly complex. The migration of neurons is affected by several natur
Precursor cell types in the germinal zone of the cerebral cortex
β Scribed by Brenda P. Williams
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 303 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0265-9247
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β¦ Synopsis
Retroviral lineage tracing experiments suggest that the cortical ventricular zone is composed of a mixture of precursor cell types. The majority generate a single cell type (neurones, astrocytes or oligodendrocytes) and the remainder generate neurones and a single type of glial cell. Pluripotential precursor cells, that have the ability to generate all three cell types, are not observed. A recent paper, however, reports that when single ventricular zone cells are cultured in isolation, a small percentage of these cells are pIuripotential(l). This review will discuss what this knowledge tells us about cortical development.
π SIMILAR VOLUMES
The cytoarchitectural simplicity of environmental signals to alter the types of cells they the cerebral cortex makes it an attractive system to generate, providing the means for feedback regulation study central nervous system (CNS) histogenesison the germinal zone. Evidence is accumulating that the
Neural stem cells are maintained in second most common cell type in this germinal layer. the subventricular zone (SVZ) of the adult mamma-The most actively proliferating cells in the SVZ, type lian brain. Here, we review the cellular organization C, form small clusters dispersed throughout the netof