Stem cells in the embryonic cerebral cortex: Their role in histogenesis and patterning

✍ Scribed by Shen, Qin ;Qian, Xueming ;Capela, Alexandra ;Temple, Sally

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 130 KB
• Volume: 36
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199808)36:2<162::aid-neu5>3.0.co;2-#

✦ Synopsis

The cytoarchitectural simplicity of environmental signals to alter the types of cells they the cerebral cortex makes it an attractive system to generate, providing the means for feedback regulation study central nervous system (CNS) histogenesison the germinal zone. Evidence is accumulating that the process whereby diverse cells are generated in cortical stem cells, influenced by intrinsic programs the right numbers at the appropriate place and time. and environmental signals, actually change with de-Recently, multipotent stem cells have been implicated velopment-for example, by reducing the number in this process, as progenitor cells for diverse types of and types of neurons they produce. Age-related cortical neurons and glia. Continuous analysis of stem changes in the stem cell population may have a critical cell clone development reveals stereotyped division role in orchestrating development; whether these cells patterns within their lineage trees, highly reminiscent truly self-renew is a point of discussion. In summary, of neural lineage trees in arthropods and Caenorhabwe propose that cortical stem cells are the focus of ditis elegans. Given that these division patterns play regulatory mechanisms central to the development of a critical part in generating diverse neural types in the cortical cytoarchitecture. ᭧ 1998 John Wiley & Sons, invertebrates, we speculate that they play a similar