Lym-I is a murine IgG2, monoclonal antibody (MAb) that is B-cell specific but has greater avidity for malignant B cells when compared with normal B lymphocytes. It was originally produced by immunizing mice with nuclei of cultured cells from a patient with Burkitt's lymphoma. Ten patients with progr
Preclinical studies with radiolabeled monoclonal antibodies for treatment of patients with b-cell malignancies
β Scribed by Susan F. Vervoordeldonk; Pauline A. Merle; Eleonore F. Van Leeuwen; Albert E. G. Kr Von Dem Borne; Ineke C. M. Slaper-Cortenbach
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 612 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, which are trapped within the cell after catabolism o
A series of 34 B-cell lymphomas was studied for the presence of transferrin receptors by immunofluorescence on frozen tissue sections with a monoclonal antibody. These lymphomas were classified by light microscopic study and furthermore investigated by immunohistochemical and morphometric methods. T
This heterogeneity showed that all components of the infarcted area were not equally damaged. These isointensity transverse bands were probably the spared nerve fiber bundles projecting into the cerebellar hemisphere from the contralateral pontine nuclei. In the cerebral hemispheres, the region mos