Cytotoxicity and actin depolymerizing ac
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Kiyotake Suenaga; Noriyuki Kamei; Youko Okugawa; Masaki Takagi; Atsushi Akao; Hi
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Article
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1997
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Elsevier Science
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English
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The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.