✦ LIBER ✦

Cytotoxicity and actin depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and the natural and artificial analogs

✍ Scribed by Kiyotake Suenaga; Noriyuki Kamei; Youko Okugawa; Masaki Takagi; Atsushi Akao; Hideo Kigoshi; Kiyoyuki Yamada

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 322 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00620-8

No coin nor oath required. For personal study only.

✦ Synopsis

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.

📜 SIMILAR VOLUMES

ChemInform Abstract: Cytotoxicity and Ac

ChemInform Abstract: Cytotoxicity and Actin-Depolymerizing Activity of Aplyronine A, a Potent Antitumor Macrolide of Marine Origin, and Its Analogues.

✍ Hideo Kigoshi; Kiyotake Suenga; Masaki Takagi; Atsushi Akao; Kengo Kanematsu; No 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 1 views

Aplyronine A, a Potent Antitumor Macroli

Aplyronine A, a Potent Antitumor Macrolide of Marine Origin, and the Congeners Aplyronines B and C: Isolation, Structures, and Bioactivities.

✍ Makoto Ojika; Hideo Kigoshi; Yoshifumi Yoshida; Takeshi Ishigaki; Masanori Nisiw 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 18 KB 👁 2 views

ChemInform Abstract: Aplyronine A, a Pot

ChemInform Abstract: Aplyronine A, a Potent Antitumor Macrolide of Marine Origin, and the Congeners Aplyronines B—H: Chemistry and Biology

✍ Kiyoyuki Yamada; Makoto Ojika; Hideo Kigoshi; Kiyotake Suenaga 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 15 KB 👁 2 views

ChemInform Abstract: Aplyronine A, a Pot

ChemInform Abstract: Aplyronine A, a Potent Antitumor Substance of Marine Origin, Aplyronines B and C, and Artificial Analogues: Total Synthesis and Structure-Cytotoxicity Relationships.

✍ H. KIGOSHI; K. SUENAGA; T. MUTOU; T. ISHIGAKI; T. ATSUMI; H. ISHIWATA; A. SAKAKU 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

Absolute stereochemistry and synthesis o

Absolute stereochemistry and synthesis of aplyronines B and C, the congeners of aplyronine A, a potent antitumor substance of marine origin

✍ Kiyotake Suenaga; Takeshi Ishigaki; Akira Sakakura; Hideo Kigoshi; Kiyoyuki Yama 📂 Article 📅 1995 🏛 Elsevier Science 🌐 French ⚖ 229 KB

ChemInform Abstract: Synthesis of the Ag

ChemInform Abstract: Synthesis of the Aglycon of Aurisides A and B, Cytotoxic Macrolide Glycosides of Marine Origin.

✍ H. SONE; K. SUENAGA; Y. BESSHO; T. KONDO; H. KIGOSHI; K. YAMADA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 44 KB 👁 2 views