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Absolute stereochemistry and synthesis of aplyronines B and C, the congeners of aplyronine A, a potent antitumor substance of marine origin

โœ Scribed by Kiyotake Suenaga; Takeshi Ishigaki; Akira Sakakura; Hideo Kigoshi; Kiyoyuki Yamada


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
229 KB
Volume
36
Category
Article
ISSN
0040-4039

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Cytotoxicity and actin depolymerizing ac
โœ Kiyotake Suenaga; Noriyuki Kamei; Youko Okugawa; Masaki Takagi; Atsushi Akao; Hi ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 322 KB

The artificial analogs of aplyronine A (1), a potent cytotoxic and antitumor macrolide, were synthesized and the structure-activity (cytotoxicity and actin depolymerizing activity) studies were performed; the side chain portion in 1 was found to play a key role in both biological activities.