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Preclinical pharmacokinetics and tissue distribution of a natural cardioprotective agent astragaloside IV in rats and dogs

✍ Scribed by Wei-Dong Zhang; Chuan Zhang; Run-Hui Liu; Hui-Liang Li; Jin-Tao Zhang; Chen Mao; Sara Moran; Chun-Lin Chen

Book ID
116718623
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
216 KB
Volume
79
Category
Article
ISSN
0024-3205

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A randomized, four-way cross-over design was used to assess the disposition of the cardioprotective agent, dexrazoxane, in four male beagle dogs following single I.V. administration of 10, 25, 50, and 100mgkg-l doses. Parent drug was quantified in plasma and urine with a validated high-pressure liqu