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Preclinical Antitumor Activity of a Novel Folate-Targeted Dual Drug Conjugate

✍ Scribed by Leamon, Christopher P.; Reddy, Joseph A.; Vlahov, Iontcho R.; Westrick, Elaine; Dawson, Alicia; Dorton, Ryan; Vetzel, Marilynn; Santhapuram, Hari Krishna; Wang, Yu

Book ID
120392602
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
747 KB
Volume
4
Category
Article
ISSN
1543-8384

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## Abstract EC140 is a water soluble folate conjugate of desacetylvinblastine monohydrazide (DAVLBH), which is constructed with an endosome‐cleavable acyl hydrazone bond. This agent has proven to be active and specific against well established, subcutaneous folate receptor (FR)‐positive tumors in m