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Synthesis and Biological Evaluation of EC140: A Novel Folate-Targeted Vinca Alkaloid Conjugate

✍ Scribed by Leamon, Christopher P.; Reddy, Joseph A.; Vlahov, Iontcho R.; Kleindl, Paul J.; Vetzel, Marilynn; Westrick, Elaine

Book ID
127057472
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
157 KB
Volume
17
Category
Article
ISSN
1043-1802

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πŸ“œ SIMILAR VOLUMES

Comparative preclinical activity of the
Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145
✍ Christopher P. Leamon; Joseph A. Reddy; Iontcho R. Vlahov; Elaine Westrick; Nikk πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 418 KB

## Abstract EC140 is a water soluble folate conjugate of desacetylvinblastine monohydrazide (DAVLBH), which is constructed with an endosome‐cleavable acyl hydrazone bond. This agent has proven to be active and specific against well established, subcutaneous folate receptor (FR)‐positive tumors in m