Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate
✍ Scribed by Daniëlle M. Gerlag; Sally Hollis; Mark Layton; Jiří Vencovský; Zoltán Szekanecz; Martin Braddock; Paul P. Tak; ESCAPE Study Group
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 152 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0004-3591
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## Objective: To assess the frequency and clinical features of an acute febrile toxic reaction (aftr) in patients with refractory rheumatoid arthritis (ra) receiving combined therapy with methotrexate (mtx) and azathioprine (aza). ## Methods: A cohort of 43 ra patients being treated with mtx/aza
## Abstract ## Objective To assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of the CC chemokine receptor CCR1 antagonist MLN3897 in patients with rheumatoid arthritis (RA) receiving methotrexate (MTX). ## Methods In this phase IIa, proof‐of‐concept study, patients meeting the