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Preadsorption of polymers on glass and silica to reduce fibrinogen adsorption

✍ Scribed by Maechling-Strasser, C. ;Déjardin, Ph. ;Galin, J. C. ;Schmitt, A.

Book ID
102293144
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
485 KB
Volume
23
Category
Article
ISSN
0021-9304

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✦ Synopsis

Glass and silica beads were precoated with various polymers to obtain steric exclusion chromatography (SEC) supports which are nonadsorbant for hydrophilic macromolecules. The efficiency of this treatment was estimated by subsequent radiolabeled fibrinogen adsorption. The result obtained with a block copolymer was better than with various hydrophilic homopolymers. This ABA type block copolymer, where A is a poly(N-acetylethyleneimine) (PAEI) sequence and B a polyethylene oxide (PEO) sequence was preadsorbed at pH 4.5 and 25°C; the fibrinogen adsorption was reduced to less than 5% of the value observed on untreated solid surfaces. Thus the hemocompatibility of solid supports should be increased by precoating with this block copolymer. Results for nonporous glass beads and porous silica particles were in good correlation.

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