✦ LIBER ✦

Pre-Treatment of human osteosarcoma cells with N-methylformamide enhances P-glycoprotein expression and resistance to doxorubicin

✍ Scribed by Katia Scotlandi; Massimo Serra; Maria Cristina Manara; Pier-Luigi Lollini; Daniela Maurici; Donatella Del Bufalo; Nicola Baldini

Book ID: 102866906
Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 769 KB
Volume: 58
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910580116

No coin nor oath required. For personal study only.

✦ Synopsis

N-methylformamide (NMF), a powerful differentiating agent, has been extensively used in experimental and preclinical cancer chemotherapy studies, alone or in association with conventional anti-cancer drugs. To evaluate the use of this molecule in the treatment of osteosarcoma (OS), we have analyzed the effects of NMF and doxorubicin (DXR) on DXRsensitive and -resistant human 0 s cell lines. Our study shows that NMF exerts remarkable effects on cell proliferation and, in Saos-2 and SARG cells, also induces differentiation, as shown by increasing alkaline phosphatase activity. Moreover, NMF increases the cytotoxic activity of D X R when administered after the drug, in both DXR-sensitive and -resistant cells. However, when this agent is given before DXR. it enhances P-glycoprotein expression in U-2 0 s cell lines. This over-expression is associated with reduced DXR accumulation within cells and with significant enhancement of resistance to DXR.

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