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Pre-clinical evaluation of gadobutrol: a new, neutral, extracellular contrast agent for magnetic resonance imaging

✍ Scribed by Hubert Vogler; Johannes Platzek; Gabriele Schuhmann-Giampieri; Thomas Frenzel; Hanns-Joachim Weinmann; Bernd Radüchel; Wolf-Rüdiger Press


Book ID
116149891
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
858 KB
Volume
21
Category
Article
ISSN
0720-048X

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✍ Bernard Gallez; René Debuyst; Roger Demeure; Fernand Dejehet; Cécile Grandin; Be 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 911 KB

## Abstract In this study, we report the synthesis and the evaluation as MRI contrast agent of a new compound (nitroxyl fatty acid, NFA), where a pyrrolidinoxyl radical (3‐carboxy‐proxyl, PCA) is linked to a fatty acid moiety. Fatty acids were selected as vector because they present a high affinity