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Pravastatin and Cyclosporine Inhibit Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cell Mitogenesis: An Investigation of Mechanisms

✍ Scribed by S Katznelson; A Ramirez; R Perez; R Weiss


Book ID
117235978
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
143 KB
Volume
30
Category
Article
ISSN
0041-1345

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Proliferation of smooth muscle cells from the pulmonary arteries and aortas of fetal calves is inhibited by heparin in vitro. This effect is reversible and dose dependent. Comparisons with effects of other polysaccharides indicate that only extensively sulfated polysaccharides inhibit proliferation