✦ LIBER ✦

Practical synthesis of α-aminoalkyl-α′-chloromethylketone derivatives. Part 2: Chloromethylation of N-imine-protected amino acid esters

✍ Scribed by Tomoyuki Onishi; Takashi Nakano; Naoko Hirose; Masakazu Nakazawa; Kunisuke Izawa

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 87 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01115-7

No coin nor oath required. For personal study only.

✦ Synopsis

Chloromethylation of N-imine-protected amino acid esters followed by acid hydrolysis gave a-aminoalkyl-a%chloromethylketone as a HCl salt form in good yield without racemization. The amino group was conveniently protected with carbamate protecting reagents to give various useful intermediates for the protease inhibitors.

📜 SIMILAR VOLUMES

ChemInform Abstract: Practical Synthesis

ChemInform Abstract: Practical Synthesis of α-Aminoalkyl-α′-chloromethylketone Derivatives. Part 2. Chloromethylation of N-Imine-Protected Amino Acid Esters.

✍ Tomoyuki Onishi; Takashi Nakano; Naoko Hirose; Masakazu Nakazawa; Kunisuke Izawa 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Practical synthesis of α-aminoalkyl-α′-c

Practical synthesis of α-aminoalkyl-α′-chloromethylketone derivatives. Part 1: Chloromethylation of N-protected 3-oxazolidin-5-ones

✍ Tomoyuki Onishi; Naoko Hirose; Takashi Nakano; Masakazu Nakazawa; Kunisuke Izawa 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 69 KB

Moc; Methoxycarbonyloxy group 3 1) TMSCl, n BuLi 2) BrCH 2 Cl, n BuLi 3 steps, 76% 3) H +

ChemInform Abstract: Practical Synthesis

ChemInform Abstract: Practical Synthesis of α-Aminoalkyl-α′-chloromethylketone Derivatives. Part 1. Choromethylation of N-Protected 3-Oxazolidin-5-ones.

✍ Tomoyuki Onishi; Naoko Hirose; Takashi Nakano; Masakazu Nakazawa; Kunisuke Izawa 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

First Practical Protection of α-Amino Ac

First Practical Protection of α-Amino Acids as N,N-Benzyloxycarbamoyl Derivatives.

✍ J. Nicolas Hernandez; Victor S. Martin 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 158 KB 👁 1 views

ChemInform Abstract: Building Units for

ChemInform Abstract: Building Units for N-Backbone Cyclic Peptides. Part 3. Synthesis of Protected Nα-(ω-Aminoalkyl)amino Acids and Nα-(. omega.-Carboxyalkyl)amino Acids.

✍ D. MULLER; I. ZELTSER; G. BITAN; C. GILON 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

ChemInform Abstract: Highly Practical Me

ChemInform Abstract: Highly Practical Methodology for the Synthesis of D- and L-α- Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α- amino Acids.

✍ A. G. MYERS; J. L. GLEASON; T. YOON; D. W. KUNG 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v