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Practical synthesis of tetrasubstituted thiophenes for use in compound libraries

✍ Scribed by Bryan P. McKibben; Craig H. Cartwright; Arlindo L. Castelhano

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
222 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

Tetrasubstituted thiophenes, obtained by optimizing the multi-component reaction originally developed by Gewald, served as key templates for structural diversification and semi-automated library synthesis. Conditions were developed to carry out Gewald's reaction at room temperature and in high yield.

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