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The use of power ultrasound coupled with magnetic separation for the solid phase synthesis of compound libraries

✍ Scribed by J.Manuel Perez; Eric J. Wilhelm; Irving Sucholeiki

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 133 KB
Volume: 10
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(99)00651-4

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✦ Synopsis

AbstractÐEnhanced reaction rates are observed when power ultrasound is utilized as a substitute for mixing during solid phase organic chemical reactions on a paramagnetic support. Power ultrasound is also used to facilitate the washing of the paramagnetic support as it is magnetically separated from the reaction mixture. Selective examples from a library targeting the k-opioid receptor are presented.

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