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Practical synthesis of (S)-7-(2-isopropylamino)ethylcamptothecin hydrochloride, potent topoisomerase I inhibitor

✍ Scribed by Soon Kil Ahn; Nam Song Choi; Byeong Seon Jeong; Kye Kwang Kim; Duck Jin Journ; Joon Kyum Kim; Sang Joon Lee; Jung Woo Kim; Chung Hong II; Sang-Sup Jew

Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
210 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A practical semi‐synthetic method of (S)‐7‐(2‐isopropylamino)ethylcamptothecin hydrochloride has been developed. The Mannich reaction of (S)‐7‐methylcamptothecin with isopropylamine hydrochloride in dimethyl sulfoxide as a formaldehyde source gave the desired product in moderate yield.

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