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Practical synthesis of potential endothelin receptor antagonists of 1,4-benzodiazepine-2,5-dione derivatives bearing substituents at the C3-, N1- and N4-positions

โœ Scribed by Cheng, Ming-Fu; Yu, Hui-Ming; Ko, Bor-Wen; Chang, Yu; Chen, Ming-Yi; Ho, Tong-Ing; Tsai, Yeun-Min; Fang, Jim-Min


Book ID
111897430
Publisher
Royal Society of Chemistry
Year
2006
Tongue
English
Weight
275 KB
Volume
4
Category
Article
ISSN
1477-0520

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## Abstract Two benzodiazepine CCK antagonists __N__โ€(2,3โ€dihydroโ€1โ€[^14^C]methylโ€2โ€oxoโ€5โ€phenylโ€1H 1,4โ€benzodiazepinโ€3โ€yl)โ€benzamide **2** and __N__โ€(2,3โ€dihydroโ€1โ€[^14^C]methylโ€2โ€oxoโ€5โ€phenylโ€1Hโ€1,4โ€benzodiazepinโ€3โ€yl)โ€[^14^C]methylโ€benzamide **3** were synthesized in high yields through the reac