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Practical synthesis of chiral ligands for catalytic enantioselective cyanosilylation of ketones

✍ Scribed by Shuji Masumoto; Kazuo Yabu; Motomu Kanai; Masakatsu Shibasaki

Book ID
104250873
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
72 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

Ti(O i Pr) 4 + 1 or 2 (1 : 1) (1~10 mol %) + 71-92% 84-97% ee (R) 85-97% 62%-97 ee (S) Ln(O i Pr) 3 + 1 (1 : 2) (5~15 mol %) chiral ligands

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Practical Synthesis
ChemInform Abstract: Practical Synthesis of Chiral Ligands for Catalytic Enantioselective Cyanosilylation of Ketones.
✍ Shuji Masumoto; Kazuo Yabu; Motomu Kanai; Masakatsu Shibasaki πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 25 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: Catalytic Enantiose
ChemInform Abstract: Catalytic Enantioselective Cyanosilylation of Ketones.
✍ Yoshitaka Hamashima; Motomu Kanai; Masakatsu Shibasaki πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons βš– 26 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

Catalytic enantioselective cyanosilylati
Catalytic enantioselective cyanosilylation of ketones: improvement of enantioselectivity and catalyst turn-over by ligand tuning
✍ Yoshitaka Hamashima; Motomu Kanai; Masakatsu Shibasaki πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 67 KB

Sterical and electronical tuning of the bifunctional catalyst 1 afforded the improved catalyst 2, which promoted the cyanosilylation of ketones with higher enantioselectivity as well as with improved catalyst turn-over with a factor of up to 10. Thus, chiral quaternary a-hydroxynitriles were obtaine

Studies toward practical synthesis of (2
Studies toward practical synthesis of (20S)-camptothecin family through catalytic enantioselective cyanosilylation of ketones: improved catalyst efficiency by ligand-tuning
✍ Kazuo Yabu; Shuji Masumoto; Motomu Kanai; Dennis P. Curran; Masakatsu Shibasaki πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 128 KB

Enantioselective catalyst efficiency for the synthesis of the camptothecin family was improved through ligand-tuning. Key intermediates of two convergent syntheses of camptothecin (Curran's intermediate and Corey's intermediate) were obtained in up to 10 g scale through the catalytic enantioselectiv