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Practical synthesis of a highly functionalized thiazole ketone

✍ Scribed by Lisa F Frey; Karen M Marcantonio; Cheng-yi Chen; Debra J Wallace; Jerry A Murry; Lushi Tan; Weirong Chen; Ulf H Dolling; Edward J.J Grabowski

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
310 KB
Volume
59
Category
Article
ISSN
0040-4020

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✦ Synopsis

Compound 1 is a uniquely substituted ketone prepared via addition of a thiazole anion to an aromatic nitrile in good overall yield. An exploration into the generality of the addition of thiazole anions to nitriles allowed us to make a variety of thiazole ketones in good to excellent yields. The non-odorous thiolate-mediated demethylation reaction used in the synthesis of 1 is also presented.

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