Practical synthesis of (3S,4R)-3-[(R)-1-(tert-butyldimethylsiloxy)-ethyl]-4-(methylsulfonyl)-2-azetidinone from dibromopenicillanic acid S,S-dioxide: a penem synthon
β Scribed by Quallich, George J.; Bordner, Jon; Elliott, Mark L.; Morrissey, Peter; Volkmann, Robert A.; Wroblewska-Adams, Magdalena M.
- Book ID
- 127151302
- Publisher
- American Chemical Society
- Year
- 1990
- Tongue
- English
- Weight
- 553 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
Di-n-butyl-, triphenyl and tri-n-butyltin derivatives of 3S,4S-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl-4-[(R)-1-carboxyethyl]-2-azetidinone were synthesized and characterized. Their antitumour activity was screened against seven tumoural cell lines of human origin. Copyright
The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-ylJalany1 derivative 8 were synthesized, without purification of intermediates, from (4S~R)-22-dimethyl-4-(2-methy~propylJ-5-hydro~~thyl-l.3-dioxolane (361, in 24 and 32% overall yield, respectively, Alcohol 38 was readily p