✦ LIBER ✦

Practical asymmetric synthesis of α-methylserine derivatives under mild phase-transfer conditions

✍ Scribed by Keiji Nakayama; Keiji Maruoka

Book ID: 104095587
Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 181 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.07.013

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✦ Synopsis

The enantioselective methylation reaction of phenyloxazoline tert-butyl ester 5 using (R)-4b as a catalyst under mild phase-transfer conditions provides optically active a-methylserine derivatives in moderate yields with high enantioselectivity. Other a-alkylated serine derivatives are also achievable in high yields with high enantioselectivity by using catalytic amount of (R)-4b.

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