Practical and efficient synthesis of N-fused tricyclic indoles
β Scribed by Natalie Koay; Devin L. Tonelli; Vouy Linh Truong
- Book ID
- 104098547
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 223 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A practical and efficient synthesis of methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate derivatives 6 is reported. This synthetic approach featured the nucleophilic aromatic substitution of 2-piperidinemethanol derivatives 2 with aryl fluorides 1, and the intramolecular Heck coupling as key steps to afford the desired N-fused tricyclic indoles 6.
π SIMILAR VOLUMES
## Abstract Tricyclic ketoβindoles were synthesized by photocyclization of easily obtained enaminones in an electroβcyclic photochemical reaction. The three methods reported were chosen according to the enaminone structure. The most general procedure using oneβstep synthesis was carried out in a be
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