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Practical and efficient synthesis of N-fused tricyclic indoles

✍ Scribed by Natalie Koay; Devin L. Tonelli; Vouy Linh Truong


Book ID
104098547
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
223 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis


A practical and efficient synthesis of methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate derivatives 6 is reported. This synthetic approach featured the nucleophilic aromatic substitution of 2-piperidinemethanol derivatives 2 with aryl fluorides 1, and the intramolecular Heck coupling as key steps to afford the desired N-fused tricyclic indoles 6.


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