Practical and efficient synthesis of N-f
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Natalie Koay; Devin L. Tonelli; Vouy Linh Truong
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Article
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2011
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Elsevier Science
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French
β 223 KB
A practical and efficient synthesis of methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate derivatives 6 is reported. This synthetic approach featured the nucleophilic aromatic substitution of 2-piperidinemethanol derivatives 2 with aryl fluorides 1, and the intramolecular Heck coupling as key