PPARα agonists up-regulate organic cation transporters in rat liver cells
✍ Scribed by Sebastian Luci; Stefanie Geissler; Bettina König; Alexander Koch; Gabriele I. Stangl; Frank Hirche; Klaus Eder
- Book ID
- 116293725
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 137 KB
- Volume
- 350
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The liver plays a major role in biotransformation and elimination of various therapeutic agents and xenobiotics, many of which are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1). Oct1 is expressed at the basolateral membranes of hepatocytes and proximal renal tubu
## Abstract Monocarboxylate transporter (MCT)‐1 mediates the transport of ketone bodies and other monocarboxylic acids across the plasma membrane. MCT1 is up‐regulated by peroxisome proliferator‐activated receptor (PPAR)‐α, a transcription factor that mediates the adaptive response to fasting by up