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PPAR-γ agonist increase gefitinib's antitumor activity through PTEN expression

✍ Scribed by Lee, Sung Yong; Hur, Gyu Young; Jung, Ki Hwan; Jung, Hye Cheol; Lee, Sang Yeub; Kim, Je Hyeong; Shin, Chol; Shim, Jae Jeong; In, Kwang Ho; Kang, Kyung Ho; Yoo, Se Hwa


Book ID
119319311
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
192 KB
Volume
51
Category
Article
ISSN
0169-5002

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Increased PTEN expression due to transcr
✍ Rosemary E. Teresi; Chung-Wai Shaiu; Ching-Shih Chen; V. Krishna Chatterjee; Kri 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 271 KB

## Abstract Germline mutations in the tumor suppressor gene __PTEN__ (protein phosphatase and tensin homolog located on chromosome ten) predispose to heritable breast cancer. The transcription factor PPARγ has also been implicated as a tumor suppressor pertinent to a range of neoplasias, including