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PP32 Oncostatin M induces collagen degradation in human articular cartilage


Book ID
114348369
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
157 KB
Volume
9
Category
Article
ISSN
1063-4584

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## Abstract ## Objective To investigate the role of oncostatin M (OSM) in cell adhesion, angiogenesis, and matrix degradation in rheumatoid arthritis (RA) synovial tissue and normal human cartilage. ## Methods Human dermal microvascular endothelial cell (HDMEC) and RA synovial fibroblast (RASF)

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Objective. To investigate the effects of the interleukind (IL-6) family cytokines, such as IL-6, IL-11, leukemia inhibitory factor (LIF), and oncostatin M (OSM), on the production of tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) in human articular cartilage. Methods. Effects of IL-6 fami