## Abstract The etiology and pathophysiology of osteochondrosis remain poorly understood because it is difficult to obtain material from lesions in the early stage of this disease and because there is no satisfactory experimental animal model. We wished to determine whether there are changes in art
Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis
β Scribed by S Laverty; S O'Kouneff; M Ionescu; A Reiner; I Pidoux; C Webber; Y Rossier; R.C Billinghurst; A.R Poole
- Book ID
- 108457021
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 820 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0736-0266
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Degradation of type II collagen is thought to be a key step in the destruction of articular cartilage in patients with rheumatoid arthritis or osteoarthritis. The aim of this study was to investigate whether type II collagen degradation is associated with cartilage destruction. Type II collagen degr
Collagen type I and type II were purified from equine flexor tendon and articular cartilage, respectively. Equal amounts of these collagens were cleaved with cyanogen bromide, and 11 mixtures containing increasing proportions of type II collagen were separated in seven identical sodium dodecyl sulfa
## Abstract We investigated the effects of exerciseβinduced loading on the collagen network of equine articular cartilage. Collagen fibril architecture at a site (1) subjected to intermittent highβintensity loading was compared with that of an adjacent site (2) sustaining continuous lowβlevel load.