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PP193—Simultaneous LC-MS/MS Quantification of P-Glycoprotein and Cytochrome P450 Probe Substrates and Their Metabolites In Dried Blood Spots

✍ Scribed by Bosilkovska, M.; Deglon, J.; Samer, C.; Walder, B.; Dayer, P.; Desmeules, J.; Staub, C.; Daali, Y.


Book ID
122286679
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
59 KB
Volume
35
Category
Article
ISSN
0149-2918

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## Abstract An assay for the simultaneous analysis of pharmaceutical compounds and their metabolites from micro‐whole blood samples (__i.e__. 5 μL) was developed using an on‐line dried blood spot (on‐line DBS) device coupled with hydrophilic interaction/reversed‐phase (HILIC/RP) LC/MS/MS. Filter pa