Power analysis for case–control association studies of samples with known family histories
✍ Scribed by Bo Peng; Biao Li; Younghun Han; Christopher I. Amos
- Book ID
- 106134988
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 304 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0340-6717
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## Abstract Most previous sample size calculations for case‐control studies to detect genetic associations with disease assumed that the disease gene locus is known, whereas, in fact, markers are used. We calculated sample sizes for unmatched case‐control and sibling case‐control studies to detect
## Abstract Association studies assessing the relationship between a common polymorphism and disease generally compare allele frequencies in cases and controls. In such studies, a limited amount of information is often available about disease incidence in relatives. We hypothesised that more power