Potentiometric Titration Behaviors of a Polymer and Gel Consisting of N -Isopropylacrylamide and Acrylic Acid †
✍ Scribed by Suzuki, Hironori; Wang, Benlian; Yoshida, Ryo; Kokufuta, Etsuo
- Book ID
- 127364739
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 87 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0743-7463
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## Abstract Graft copolymers of poly(__N__‐isopropylacrylamide) (PNIPAAm) on a poly(acrylic acid) backbone retain the temperature‐induced phase transition behavior of PNIPAAm over a wide range of compositions even at pH 7,4 and should be useful for sustained‐release, bioadhesive drug delivery syste
A series of pH-thermoreversible hydrogels are prepared from the three molar ratios of N-isopropylacrylamide (NIPAAm) and acrylic acid neutralized 50 mol % by sodium hydroxide (SA50) and N,NЈ-methylene bisacrylamide (NMBA). The influence of the environmental conditions, such as temperature and pH val