## Abstract __N__โIsopropylacrylamide/acrylic acid copolymer hydrogels were synthesized with ultrasound. The thermoresponsive phase behaviors of gels synthesized with ultrasound (US gels) were investigated and compared with those of gels synthesized in the absence of ultrasound (FR gels). The US ge
Temperature-induced phase transition behaviors of random vs. graft copolymers of N-isopropylacrylamide and acrylic acid
โ Scribed by Guohua Chen; Allan S. Hoffman
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 360 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1022-1336
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โฆ Synopsis
Abstract
Graft copolymers of poly(Nโisopropylacrylamide) (PNIPAAm) on a poly(acrylic acid) backbone retain the temperatureโinduced phase transition behavior of PNIPAAm over a wide range of compositions even at pH 7,4 and should be useful for sustainedโrelease, bioadhesive drug delivery systems at physiologic conditions.
๐ SIMILAR VOLUMES
A series of temperature-responsive hydrogels were prepared by grafting oligo(N-isopropylacrylamide) (ONIPAAm) chains onto a crosslinked poly(acrylic acid) (PAAc) network, intending an application to drug delivery systems (DDS). Cloud points and swelling ratios of the obtained PAAc-graft-ONIPAAm gels