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Potentiation ofcis-diamminedichloroplatinum nephrotoxicity by amikacin in rats

✍ Scribed by Hermina T. M. Jongejan; Abraham P. Provoost; Jan C. Molenaar

Book ID: 104687127
Publisher: Springer
Year: 1988
Tongue: English
Weight: 229 KB
Volume: 22
Category: Article
ISSN: 0344-5704
DOI: 10.1007/bf00257319

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✦ Synopsis

The nephrotoxic interaction between cis-diamminedichloroplatinum (CDDP) and amikacin (AMI) was studied in rats. Following a single dose of CDDP (5 mg/kg i.v.), AMI (60 mg/kg s.c.) was given for 14 days. When given alone CDDP caused a 40% fall in the glomerular filtration rate (GFR), whereas AMI alone had no effect on GFR. This nonnephrotoxic course of AMI potentiated the CDDP-induced fall in GFR. Only a limited recovery of renal function was observed during a 15-week follow-up period.

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