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Potentiation of Tyramine Effect on the Isolated Iris Muscle by Cocaine

✍ Scribed by Lagercrantz, H.


Book ID
114865364
Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
248 KB
Volume
73
Category
Article
ISSN
0001-6772

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We investigated the effect of pilocarpine on the bovine iris sphincter. This muscle contracted in a dose-dependent manner from 2 x 10(-6) M, with a maximal response at 3 x 10(-3) M. The ED50 values was (1.6 +/- 0.3) x 10(-4) M. Pilocarpine generated a desensitization while desensitization was not si