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Potentiation of mitomycin C cytotoxicity by glutathione depletion in a multi-drug resistant mouse leukemia cell line

โœ Scribed by Xu, Bing H.; Singh, Shivendra V.


Book ID
123404801
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
432 KB
Volume
66
Category
Article
ISSN
0304-3835

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A novel fluorometric microculture cytotoxicity assay (FMCA), based on measurements of fluorescein diacetate (FDA) hydrolysis and DNA staining by Hoechst 33342, was used for drug sensitivity testing and detection of resistance reversal in acute lymphoblastic leukemia (ALL) cell lines. The 72-hr assay