Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin
โ Scribed by Hayashi, Kyoko; Hayashi, Toshimitsu; Sun, Han-Dong; Takeda, Yoshio
- Book ID
- 110017643
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 143 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0929-1903
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## Abstract ## Background Ganciclovir exhibits broadโspectrum activity against DNA viruses such as cytomegaloviruses, herpes simplex viruses, varicellaโzoster virus, EpsteinโBarr virus and human herpes virusโ6. Ganciclovir is widely applied for antiโherpetic treatment, cytomegalovirus prophylaxis
## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSVโTK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea