Crystal structures of the thymidine kinase from herpes simplex virus type-I in complex with deoxythymidine and Ganciclovir
โ Scribed by Brown, D.G.; Visse, R.; Sandhu, G.; Davies, A.; Rizkallah, P.J.; Melitz, C.; Summers, W.C.; Sanderson, M.R.
- Book ID
- 109965196
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 752 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1072-8368
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## Abstract We have earlier demonstrated that inhibition of polyamine biosynthesis with difluoromethylornithine (DFMO) can be used to enhance the cytotoxicity of herpes simplex virus thymidine kinase/ganciclovir (HSVโTK/GCV) gene therapy in different tumor cell lines. Here, the utility of this trea
## Abstract ## Background Ganciclovir exhibits broadโspectrum activity against DNA viruses such as cytomegaloviruses, herpes simplex viruses, varicellaโzoster virus, EpsteinโBarr virus and human herpes virusโ6. Ganciclovir is widely applied for antiโherpetic treatment, cytomegalovirus prophylaxis