Potentiation of domperidone-induced catalepsy by a P-glycoprotein inhibitor, cyclosporin A
β Scribed by Kenji Tsujikawa; Yukihiko Dan; Kiyoko Nogawa; Hitoshi Sato; Yasuhiko Yamada; Hideyasu Murakami; Hisakazu Ohtani; Yasufumi Sawada; Tatsuji Iga
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 143 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.343
No coin nor oath required. For personal study only.
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The effect of inhibition of monoamine oxidase (M\_AO), catechol-Omethyltransferase (COMT) and Dopa-decarboxylase on the catalepsy induced by d-amphetamine in ~-methyl-p-tyrosine (a-MpT) treated rats has been investigated. Administration of an MAO inhibitor concomitant with a-MpT slightly antagonize
## Abstract A major concern regarding the chronic administration of antiretroviral drugs is the potential for induction of drug efflux transporter expression (i.e., Pβglycoprotein, Pβgp) at tissue sites that can significantly affect drug distribution and treatment efficacy. Previous data have shown