Inhibition of cell-mediated cytolysis and P-glycoprotein function in natural killer cells by verapamil isomers and cyclosporine a analogs

Leukemic blast and natural killer cell P

Leukemic blast and natural killer cell P-glycoprotein function and inhibition in a clinical trial of zosuquidar infusion in acute myeloid leukemia

✍ John F. Marcelletti; Pratik S. Multani; Jeffrey E. Lancet; Maria R. Baer; Branim 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 356 KB

A bioassay was developed to assess P-glycoprotein (P-gp) function of peripheral blood natural killer (NK) cells and AML blasts during zosuquidar infusion. Cells were incubated with the fluorescent dye DiOC(2)(3) in the presence and absence of zosuquidar, and dye accumulation measured by flow cytomet