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Potential Tumor-Selective Nitroimidazolylmethyluracil Prodrug Derivatives: Inhibitors of the Angiogenic Enzyme Thymidine Phosphorylase

✍ Scribed by Cole, Christian; Reigan, Philip; Gbaj, Abdul; Edwards, Philip N.; Douglas, Kenneth T.; Stratford, Ian J.; Freeman, Sally; Jaffar, Mohammed

Book ID
115472027
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
116 KB
Volume
46
Category
Article
ISSN
0022-2623

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## Abstract The expression of thymidine phosphorylase (TP) is strongly associated with angiogenesis in tumors and activation of antitumor agents. We designed a novel 5‐^125^I‐labeled 6‐(2‐iminoimidazolidinyl)methyluracil hydrochloride ([^125^I]5I6IMU‐HCl) to develop an effective radiotracer for __i