Potential-surface calculation for a model addition of a nucleophilic reagent to a carbonyl compound in the vapor state and in an aqueous medium

Adamantanone : A model to assess the pos

Adamantanone : A model to assess the position of the transition state in nucleophilic addition reactions to carbonyl compounds.

✍ P. Geneste; G. Lamaty; C. Moreau; J-P. Roque 📂 Article 📅 1970 🏛 Elsevier Science 🌐 French ⚖ 218 KB

As we haVe previously pointed out], the position of the Transition State along the reaction coordinate is a matter of controversy among workers in the field of nucleophilic addition reactions to carbonyl compounds. Some authors claim that the transition state is always "Reactant-like" whatever may b