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Potential Role of Histone Deacetylase Inhibitors in Mesothelioma: Clinical Experience with Suberoylanilide Hydroxamic Acid

โœ Scribed by Lee M. Krug; Tracy Curley; Lawrence Schwartz; Stacie Richardson; Paul Marks; Judy Chiao; W. Kevin Kelly


Book ID
119935537
Publisher
CIG Media Group, LP.
Year
2006
Tongue
English
Weight
564 KB
Volume
7
Category
Article
ISSN
1525-7304

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## Abstract Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single age