## Abstract Neuronal degeneration and aberrant neovascularization are common problems of ischemic retinopathies. Pigment epithelium‐derived factor (PEDF), a neuroprotective protein and an inhibitor of angiogenesis, is produced by retinal glial (Müller) cells and can counterbalance elevated levels o
Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration
✍ Scribed by C Harada; T Harada; H.-M.A Quah; F Maekawa; K Yoshida; S Ohno; K Wada; L.F Parada; K Tanaka
- Book ID
- 117491397
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 483 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0306-4522
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Glial cell line‐derived neurotrophic factor (GDNF) enhances the survival of a variety of neurons, including photoreceptors (PR) in the retina. In contrast to most other GDNF receptive neurons, GDNF does, however, not exert its neuroprotective activity directly on PR neurons but transmit
Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli