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Role of PI3-K/Akt pathway and its effect on glial cell line-derived neurotrophic factor in midbrain dopamine cells

✍ Scribed by Hong-jun WANG; Jun-ping CAO; Jing-kao YU; Dian-shuai GAO


Book ID
111355145
Publisher
Nature Publishing Group
Year
2007
Tongue
Chinese
Weight
817 KB
Volume
28
Category
Article
ISSN
1671-4083

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Parkinson's disease is characterized by the progressive degeneration of midbrain dopaminergic neurons. Several studies have examined the effects of the dopaminergic neurotrophins growth/differentiation factor 5 (GDF5) and glial cell line-derived neurotrophic factor (GDNF) on these neurons in vitro.