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Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer

✍ Scribed by M.T. Romanish; C.J. Cohen; D.L. Mager

Book ID
113900457
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
242 KB
Volume
20
Category
Article
ISSN
1044-579X

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## Abstract Genomic instability is a hallmark of most human cancers including high‐risk human papillomavirus (HPV)‐associated anogenital neoplasia. The two HPV‐encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning