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Mechanisms of genomic instability in human cancer: Insights from studies with human papillomavirus oncoproteins

✍ Scribed by Stefan Duensing; Karl Münger

Book ID
102275041
Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
172 KB
Volume
109
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Genomic instability is a hallmark of most human cancers including high‐risk human papillomavirus (HPV)‐associated anogenital neoplasia. The two HPV‐encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV‐induced genomic instability and discuss its significance in the context of human carcinogenesis. © 2003 Wiley‐Liss, Inc.

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