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Potential involvement of serine/threonine protein phosphatases in apoptosis of HepG2 cells during selenite treatment

โœ Scribed by Handan Ak Celik; Fatih Kircelli; Guray Saydam; Himet Hakan Aydin


Book ID
110630499
Publisher
Humana Press Inc
Year
2007
Tongue
English
Weight
521 KB
Volume
117
Category
Article
ISSN
0163-4984

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S-adenosylmethionine (SAMe) and its metabolite 5-methylthioadenosine (MTA) are proapoptotic in HepG2 cells. In microarray studies, we found SAMe treatment induced Bcl-x expression. Bcl-x is alternatively spliced to produce two distinct mRNAs and proteins, Bcl-x L and Bcl-x S . Bcl-x L is antiapoptot