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Potential inhibitory effects of formulation ingredients on intestinal cytochrome P450

✍ Scribed by Richard J. Mountfield; Sandrine Senepin; Michael Schleimer; Isabelle Walter; Beate Bittner


Book ID
108453916
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
75 KB
Volume
211
Category
Article
ISSN
0378-5173

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The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three quinolines, oxamniquine, primaquine and chloroquine inhibited microsomal CYP2D6-catalysed formation of l'hydroxybufuralol at concentrations tha